Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
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In this issue...
In the News
Ethical, Legal, and Social Issues and Educational Resources
Genetics in Medicine
Web, Other Resources, Publications
Meeting Calendars & Acronyms
PEDANT is a software system for completely automatic and exhaustive analysis of protein sequence sets, from individual sequences to complete genomes. This server now contains 20 complete genomic sequences and 1 plasmid, as well as 21 experimental and unfinished genomic sequences.
Entries for completed genomes include three sections:
Release 6 of TREMBL, a protein sequence database that supplements SWISS-PROT, has been announced. TREMBL contains the translations of all EMBL Nucleotide Sequence Database coding sequences not yet integrated into SWISS-PROT. Weekly TREMBL updates are available by anonymous ftp and from the Sequence Retrieval System server of the European Bioinformatics Institute. [Contact: firstname.lastname@example.org]
One of the four R&D 100 awards won by Los Alamos National Laboratory in 1998 was for SOLVE, a system that produces 3-D pictures of protein structure. SOLVE automatically carries out all the steps necessary to fill in missing information in X-ray crystallography, a process that uses X rays to determine the structure of atoms, ions, or molecules in chemical substances. SOLVE's speed and ease of operation make it suitable for the rapid analysis of protein molecule shapes, and accurate protein pictures can be produced in hours rather than days. In addition, the automated system can evaluate hundreds of solutions and can be operated by a novice. SOLVE shows promise in helping researchers design new and improved drugs, enzymes for rapidly breaking down toxic waste or synthesizing useful chemicals, and heat-tolerant enzymes useful in chemical manufacturing processes.
Technologies funded by DOE accounted for 34 of the 100 R&D awards in 1998. [SOLVE Contact: Thomas Terwilliger 505/667-0072]
Axys Pharmaceuticals Inc. of South San Francisco, California, has been awarded a Phase I Small Business Innovation Research grant from the NIH National Institute of General Medical Sciences to conduct a 6-month research study of proteomics. Proteomics is the global search for and identification and prediction of protein function. The Axys goal is to build the ProteomeBank, a software system and proprietary database of protein families for high-throughput, accurate prediction of protein function.
A database of genes characterized since completion of the Escherichia coli genome sequence lists new and old gene names, SWISS-PROT entry, gene location, genetic structure, and identified function.
The electronic form of the newsletter may be cited in the following style:
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.