Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
In this issue...
Also available in pdf.
1997 Santa Fe Highlights
Human Genome Project Administration
In the News
Software and the Internet
Meeting Calendars & Acronyms
Data Surge Challenges Informatics Developers
The explosive growth of sequence and biological information poses pressing challenges for data acquisition, representation, access, and analysis. Some highlights from informatics sessions at the Santa Fe workshop follow.
bioWidgets: Adaptable, Reusable Modules for Viewing Data
Querying Across Databases with BioKleisli
Improved BCM Search Launcher
WIT/WIT2: Reconstructing Metabolism Analysis of the increasing number of fully or partially sequenced small genomes can serve as the foundation from which to look at more complex genomes. Evgeni Selkov and Ross Overbeek (both at Argonne National Laboratory) discussed the reconstruction of accurate metabolism models for 29 of these small organisms. Using sequence data supplemented with biochemical and phenotypic data, the group has made reconstructions (some based on still-incomplete sequence data) available via the WIT/WIT2 system. WIT2 is a UNIX-based system in two parts: a Web-based, data-access system and a set of batch tools offering extensible data-query access (http://wit.mcs.anl.gov/WIT2/wit.html).
WIT/WIT2 reconstructions are based on the metabolic pathway (MPW) collection, which includes over 2800 diagrams covering primary and secondary metabolism, membrane transport, signal-transduction pathways, intracellular traffic, transcription, and translation. Selkov observed that identifying universal metabolic aspects and gene families will lead to integrated understanding of metabolic evolution and to technologies for developing higher-level functional models. In the current public release of MPW (http://wit.mcs.anl.gov/MPW/), the coding, based on the pathways' logical structure, is represented by objects commonly used in electronic circuit design. Such design facilitates diagram drawing and editing and enables automation of basic simulation operations.
The electronic form of the newsletter may be cited in the following
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.
Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.