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Human Genome News Archive Edition
Vol.9, No.3   July 1998

In this issue... 

Also available in pdf.

1997 Santa Fe Highlights

Human Genome Project Administration

In the News

Publications

Software and the Internet

Funding

Meeting Calendars & Acronyms

  • Genome and Biotechnology Meetings 
  • Training Courses and Workshops 
  • Acronyms

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C. Elegans Sequencing Project Nears Finish

At the 1997 Santa Fe meeting, NIH-funded researcher Stephanie Chissoe [Washington University, St. Louis (WUSTL)] provided an overview of the final, closure phases of the project to sequence the 100-Mb genome of the roundworm Caenorhabditis elegans. Working in equal collaboration with the Sanger Center (Hinxton, U.K.), researchers expect completion by the end of this year, making another major achievement in the Human Genome Project.

A clone-based sequence-ready map provided the majority of sequencing substrates, including cosmids and YACs. Analysis and annotation of the finished sequence include identification of potential exons by similarity to EST data and known protein sequences and by gene-prediction programs. Before submission to GenBank, the generated data sets are read into the ACeDB database and reconciled manually with each other and with ancillary C. elegans map data. Thus far the teams have identified 13,747 annotated genes in 71.4 MB of annotated sequence from the February 1998 ACeDB release. Some 30% match a C. elegans EST, and 55% have some similarity. About half of C. elegans genes lack significant database hits that are likely to provide clues to function, Chissoe noted, so WUSTL investigators are generating C. briggsae comparative sequencing data.


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Human Genome Program, U.S. Department of Energy, Human Genome News (v9n3).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.