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Human Genome News Archive Edition
  Vol.10, No.1-2   February 1999
Available in PDF 
In this issue... 

Genome Project 

In the News 

Microbial Genomics 

Ethical, Legal, and Social Issues and Educational Resources 


Genetics in Medicine 


Web, Other Resources, Publications 


Meeting Calendars & Acronyms 

  • Genome and Biotechnology Meetings 
  • Training Courses and Workshops 
  • Acronyms 

HGN archives and subscriptions 
HGP Information home

Proteomics News

Tool for Protein Analysis

PEDANT is a software system for completely automatic and exhaustive analysis of protein sequence sets, from individual sequences to complete genomes. This server now contains 20 complete genomic sequences and 1 plasmid, as well as 21 experimental and unfinished genomic sequences.

Entries for completed genomes include three sections:

  • General Information such as genome summary, open reading frames, links, and search mechanism;
  • Protein Function such as closest homologues, functional categories, Protein Information Resource keywords and superfamilies, and PROSITE patterns; and
  • Protein Structure such as known 3-D, transmembrane, signal-peptide, low-complexity, coiled-coil, and structural classes.

TREMBL Release 6

Release 6 of TREMBL, a protein sequence database that supplements SWISS-PROT, has been announced. TREMBL contains the translations of all EMBL Nucleotide Sequence Database coding sequences not yet integrated into SWISS-PROT. Weekly TREMBL updates are available by anonymous ftp and from the Sequence Retrieval System server of the European Bioinformatics Institute. [Contact:]

R&D 100 Award to LANL's SOLVE

One of the four R&D 100 awards won by Los Alamos National Laboratory in 1998 was for SOLVE, a system that produces 3-D pictures of protein structure. SOLVE automatically carries out all the steps necessary to fill in missing information in X-ray crystallography, a process that uses X rays to determine the structure of atoms, ions, or molecules in chemical substances. SOLVE's speed and ease of operation make it suitable for the rapid analysis of protein molecule shapes, and accurate protein pictures can be produced in hours rather than days. In addition, the automated system can evaluate hundreds of solutions and can be operated by a novice. SOLVE shows promise in helping researchers design new and improved drugs, enzymes for rapidly breaking down toxic waste or synthesizing useful chemicals, and heat-tolerant enzymes useful in chemical manufacturing processes.

Technologies funded by DOE accounted for 34 of the 100 R&D awards in 1998. [SOLVE Contact: Thomas Terwilliger 505/667-0072]

NIH Proteomics Grant to Axys

Axys Pharmaceuticals Inc. of South San Francisco, California, has been awarded a Phase I Small Business Innovation Research grant from the NIH National Institute of General Medical Sciences to conduct a 6-month research study of proteomics. Proteomics is the global search for and identification and prediction of protein function. The Axys goal is to build the ProteomeBank, a software system and proprietary database of protein families for high-throughput, accurate prediction of protein function.

Completing the E. coli Proteome

A database of genes characterized since completion of the Escherichia coli genome sequence lists new and old gene names, SWISS-PROT entry, gene location, genetic structure, and identified function.

The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v10n1-2).

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Acronym List

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.