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Human Genome News Archive Edition
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Vol.9, No.3   July 1998

In this issue... 

Also available in pdf.

1997 Santa Fe Highlights

Human Genome Project Administration

In the News


Software and the Internet


Meeting Calendars & Acronyms

  • Genome and Biotechnology Meetings 
  • Training Courses and Workshops 
  • Acronyms

HGN archives and subscriptions
HGP Information home

Microbial Genome News

TIGR Sequencing Six More Microbes

The DOE Microbial Genome Program (MGP) aims to determine the sequence of bacteria having potential usefulness in energy, environmental, and evolutionary research. (http://www.er.doe.gov/production/ober/HELSRD_top.html) With the support of MGP, The Institute for Genomic Research (TIGR) and its collaborators are sequencing the genomes of an additional six microbes.

  • Pseudomonas putida (5.0 Mb)
  • Thiobacillus ferroxidans (2.9 Mb)
  • Desulfovibrio vulgaris (1.7 Mb)
  • Caulobacter crescentus (3.8 Mb) with Lucille Shapiro (Stanford University) and Bert Ely (University of South Carolina)
  • Chlorobium tepidum (2.1 Mb)
  • Dehalococcoides ethenogenes

Tuberculosis Microbe Sequenced
New Drugs, Vaccines May Result
In June researchers reported obtaining the DNA sequence of the complete 4.4-Mb genome of Mycobacterium tuberculosis, the organism that causes tuberculosis. The sequence is the first completed at The Wellcome Trust Pathogen Genome Unit at the Sanger Centre, U.K.

An estimated 2.9 million people died from this chronic infectious disease in 1997, and concern is growing over new antibiotic-resistant strains that have emerged in recent years. According to a Nature online special report on the global tuberculosis epidemic (http://www.nature.com), about one in every three people in the world is infected with M. tuberculosis, and each has an estimated 10% lifetime risk of progressing to clinical disease. Scientists hope that knowledge of the DNA sequence will provide clues to designing more effective therapeutic agents and vaccines.

The sequence, reported in the June 11 issue of Nature (393, 537-44), is accessible from the Sanger Centre Web site (http://www.sanger.ac.uk/Projects/M_tuberculosis).

Searching TB Genome
A tool is available through the South African National Bioinformatics Institute [http://www.uwc.ac.za/Faculties/NS/SANBI/Pages/default.aspx] for searching and extracting genome sequence and open reading frames from the genome of M. tuberculosis. Searches also can be performed against incomplete M. leprae data. (http://ziggy.sanbi.ac.za/tb/tbsearch.htm)

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The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v9n3).

Human Genome Project 1990–2003

The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.

Human Genome News

Published from 1989 until 2002, this newsletter facilitated HGP communication, helped prevent duplication of research effort, and informed persons interested in genome research.