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In this issue...
Also available in pdf.
1997 Santa Fe Highlights
Human Genome Project Administration
In the News
Software and the Internet
Meeting Calendars & Acronyms
The DOE Microbial Genome Program (MGP) aims to determine the sequence of bacteria having potential usefulness in energy, environmental, and evolutionary research. (http://www.er.doe.gov/production/ober/HELSRD_top.html) With the support of MGP, The Institute for Genomic Research (TIGR) and its collaborators are sequencing the genomes of an additional six microbes.
Tuberculosis Microbe Sequenced
New Drugs, Vaccines May Result
In June researchers reported obtaining the DNA sequence of the complete 4.4-Mb genome of Mycobacterium tuberculosis, the organism that causes tuberculosis. The sequence is the first completed at The Wellcome Trust Pathogen Genome Unit at the Sanger Centre, U.K.
An estimated 2.9 million people died from this chronic infectious disease in 1997, and concern is growing over new antibiotic-resistant strains that have emerged in recent years. According to a Nature online special report on the global tuberculosis epidemic (http://www.nature.com), about one in every three people in the world is infected with M. tuberculosis, and each has an estimated 10% lifetime risk of progressing to clinical disease. Scientists hope that knowledge of the DNA sequence will provide clues to designing more effective therapeutic agents and vaccines.
The sequence, reported in the June 11 issue of Nature (393, 537-44), is accessible from the Sanger Centre Web site (http://www.sanger.ac.uk/Projects/M_tuberculosis).
Searching TB Genome
A tool is available through the South African National Bioinformatics Institute [http://www.uwc.ac.za/Faculties/NS/SANBI/Pages/default.aspx] for searching and extracting genome sequence and open reading frames from the genome of M. tuberculosis. Searches also can be performed against incomplete M. leprae data. (http://ziggy.sanbi.ac.za/tb/tbsearch.htm)
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v9n3).
The Human Genome Project (HGP) was an international 13-year effort, 1990 to 2003. Primary goals were to discover the complete set of human genes and make them accessible for further biological study, and determine the complete sequence of DNA bases in the human genome. See Timeline for more HGP history.