Archive Site Provided for Historical Purposes
Sponsored by the U.S. Department of Energy Human Genome Program
In this issue...
Also available in pdf.
1997 Santa Fe Highlights
Human Genome Project Administration
In the News
Software and the Internet
Meeting Calendars & Acronyms
Survey Identifies Growing Need for Synchrotron Analyses
Structural Biology and Synchrotron Radiation: Evaluation of Resources and Needs (1997) is a report on the current status of biological uses and demands of synchrotron radiation in the United States. For this report, staff at the synchrotron radiation facilities and their user communities were surveyed, and a group of experienced structural biologists analyzed the data.
In evaluating what synchrotron facilities and support operations are needed and in anticipating future requirements for sustaining the exciting progress in structural biology, the BioSync Committee noted the expanded impact of structural biology in recent years. This expansion has led to an increase in the size and complexity of macromolecular structures being determined and in the difficulty of experiments being pursued. Structural biology is having a widening effect on such diverse fields as immunology, neurobiology, cell biology, virology, physiology, molecular biology, medicine, and biotechnology.
Recent advances in structural biology can be attributed to (1) methodological improvements that allow a vast array of cellular proteins to be cloned and expressed in quantities sufficient for structural studies, (2) use of cryocrystallography to prepare extremely stable crystals, and (3) availability of and technological innovations at synchrotron radiation facilities (see Envisioning the Proteome.) These factors have brought many more projects of high biological significance into the realm of structural biology. Without synchrotron sources, many of these new research projects could not have been undertaken.
The BioSync Committee reached the following main conclusions:
1997 BioSync Report
The electronic form of the newsletter may be cited in the following style:
Human Genome Program, U.S. Department of Energy, Human Genome News (v9n3).